Surfactant protein D , a marker of lung innate immunity , is positively associated with insulin resistance
نویسندگان
چکیده
Department of Diabetes, Endocrinology and Nutrition. Institut d’Investigació Biomèdica de Girona. CIBER Fisiopatología de la Obesidad y Nutrición CB06/03/010, Girona. SPAIN Department of Endocrinology and Nutrition, Hospital Central de Asturias, Oviedo, Spain. 3 Scientific Directorate, Bambino Gesù Hospital; Rome. Italy Department of Endocrinology, Clínica Universitaria de Navarra and CIBEROBN (CB06/03/010), Instituto de Salud Carlos III, Spain. Hormonal Laboratory, Hospital Clínic, Barcelona, Spain. 6 Department of Internal Medicine, Catholic University School of Medicine, Rome. Italy
منابع مشابه
Surfactant Protein D, a Marker of Lung Innate Immunity, Is Positively Associated With Insulin Sensitivity
OBJECTIVE Impaired lung function and innate immunity have both attracted growing interest as a potentially novel risk factor for glucose intolerance, insulin resistance, and type 2 diabetes. We aimed to evaluate whether surfactant protein D (SP-D), a lung-derived innate immune protein, was behind these associations. RESEARCH DESIGN AND METHODS Serum SP-D was evaluated in four different cohort...
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Host defense roles for the lung collectins, surfactant protein A (SP-A) and surfactant protein D (SP-D), were first suspected in the 1980s when molecular characterization revealed their sequence homology to the acute phase reactant of serum, mannose-binding lectin. Surfactant protein A and SP-D have since been shown to play diverse and important roles in innate immunity and pulmonary homeostasi...
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